La lista de nominados encabezada por el juego indie Limbo son:
Best Game Design Super Mario Galaxy 2 (Nintendo) Mass Effect 2 (BioWare) Limbo (Playdead) Red Dead Redemption (Rockstar San Diego) God of War III (SCE Santa Monica)
Innovation Heavy Rain (Quantic Dream) Kirby's Epic Yarn (Good-Feel & HAL Laboratory) Minecraft (Mojang) Limbo (Playdead) Dance Central (Harmonix)
Best Technology Starcraft II (Blizzard) Red Dead Redemption (Rockstar San Diego) Heavy Rain (Quantic Dream) Mass Effect 2 (BioWare) God of War III (SCE Santa Monica)
Best Handheld Game God of War: Ghost of Sparta (Ready At Dawn/SCE Santa Monica) Cut the Rope (ZeptoLab) Metal Gear Solid: Peace Walker (Kojima Productions) Game Dev Story (Kairosoft) Dragon Quest IX (Level 5)
Best Audio Limbo (Playdead) Red Dead Redemption (Rockstar San Diego) Halo: Reach (Bungie) Battlefield: Bad Company 2 (DICE) Mass Effect 2 (BioWare)
Best Downloadable Game Costume Quest (Double Fine) Limbo (Playdead) Super Meat Boy (Team Meat) Minecraft (Mojang) Monday Night Combat (Uber Entertainment)
Best Writing Red Dead Redemption (Rockstar San Diego) Heavy Rain (Quantic Dream) Mass Effect 2 (BioWare) Costume Quest (Double Fine) Fallout: New Vegas (Obsidian)
Best Debut Game Limbo (Playdead) Darksiders (Vigil Games) Minecraft (Mojang) Monday Night Combat (Uber Entertainment) Super Meat Boy (Team Meat)
Best Visual Arts God of War III (SCE Santa Monica) Limbo (Playdead) Call of Duty: Black Ops (Treyarch) Assassin's Creed: Brotherhood (Ubisoft Montreal) Red Dead Redemption (Rockstar San Diego)
Game of the Year Red Dead Redemption (Rockstar San Diego) Mass Effect 2 (BioWare) Call of Duty: Black Ops (Treyarch) Limbo (Playdead) Assassin's Creed: Brotherhood (Ubisoft Montreal)