Sí, ese código de error tiene que ver con el lector:
Un cuadrante parpadea en rojo
Significado: Error de hardware. En la pantalla se mostrara el código de error.
E45: Unknown (possibly dashboard update related)
E64: DVD Drive Error.... DVD Timeout, Wrong firmware, dvd is without f/w chip, etc.
E65: DVD Drive Error.... DVD Timeout, Wrong firmware, dvd is without f/w chip, etc. This can also be caused by the tray not being fully closed on boot.
E66: DVD Drive Error: DVD model, or version does not match that of the version expected by the dashboard. OR the firmware version on the drive is older then the firmware version expected by the dashboard. Make sure the DVD drive is of the same version originally included with the console and that it is using either the original firmware included with the console or newer.